منابع مشابه
Toll-like receptor 4 modulates skeletal muscle substrate metabolism.
Toll-like receptor 4 (TLR4), a protein integral to innate immunity, is elevated in skeletal muscle of obese and type 2 diabetic humans and has been implicated in the development of lipid-induced insulin resistance. The purpose of this study was to examine the role of TLR4 as a modulator of basal (non-insulin-stimulated) substrate metabolism in skeletal muscle with the hypothesis that its activa...
متن کاملSkeletal Muscle Function and Metabolism
Skeletal muscle consists of bundles of long spindle shaped cells called muscle fibers that attach to bone by tendinous insertions. The blood vessels and nerves that nourish and control muscle function run in thin sheets of connective tissue that surround bundles of muscle fibers. Each nerve branch communicates with one muscle fiber at the motor end. The nerve and all the muscle fibers that it s...
متن کاملSkeletal muscle Nur 77 expression enhances oxidative metabolism and substrate utilization
The mitochondrion is an indispensable component for cellular respiration. To meet ongoing energy demands, cells up-regulate oxidative metabolism to boost ATP production. In skeletal muscle, a number of transcriptional factors have been shown to affect mitochondrial function and biogenesis. Peroxisome proliferator activated receptor coactivator 1 (Pgc1 ), for instance, coactivates a number ...
متن کاملSkeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization[S]
Mitochondrial dysfunction has been implicated in the pathogenesis of type 2 diabetes. Identifying novel regulators of mitochondrial bioenergetics will broaden our understanding of regulatory checkpoints that coordinate complex metabolic pathways. We previously showed that Nur77, an orphan nuclear receptor of the NR4A family, regulates the expression of genes linked to glucose utilization. Here ...
متن کاملGender Differences in Skeletal Muscle Substrate Metabolism – Molecular Mechanisms and Insulin Sensitivity
It has become increasingly apparent that substrate metabolism is subject to gender-specific regulation, and the aim of this review is to outline the available evidence of molecular gender differences in glucose and lipid metabolism of skeletal muscle. Female sex has been suggested to have a favorable effect on glucose homeostasis, and the available evidence from hyperinsulinemic-euglycemic clam...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 1999
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0800878